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Single-dose pharmacokinetics of clomiphene citrate in normal volunteers April 18 is the 108th day of the year (109th in leap years) in the Gregorian calendar. There are 257 days remaining until the end of the year.
On this day in 1775, British troops march out of Boston on a mission to confiscate the American arsenal at Concord and to capture Patriot leaders Samuel Adams and John Hancock, known to be hiding at Lexington. As the British departed, Boston Patriots Paul Revere and William Dawes set out on horseback from the city to warn Adams and Hancock and rouse the Minutemen.
By 1775, tensions between the American colonies and the British government had approached the breaking point, especially in Massachusetts, where Patriot leaders formed a shadow revolutionary government and trained militias to prepare for armed conflict with the British troops occupying Boston. In the spring of 1775, General Thomas Gage, the British governor of Massachusetts, received instructions from Great Britain to seize all stores of weapons and gunpowder accessible to the American insurgents. On April 18, he ordered British troops to march against Concord and Lexington.
On the night of April 18-19, 1775, just hours before the battles of Lexington and Concord, Revere performed his “Midnight Ride”. He and William Dawes were instructed by Dr. Joseph Warren to ride from Boston to Lexington to warn John Hancock and Samuel Adams of the movements of the British Army, which was beginning a march from Boston to Lexington, ostensibly to arrest Hancock and Adams and seize the weapons stores in Concord.
The British army (the King’s “regulars”) had been stationed in Boston since the ports were closed in the wake of the Boston Tea Party, and was under constant surveillance by Revere and other patriots as word began to spread that they were planning a move. On the night of April 18, 1775, the army began its move across the Charles River toward Lexington, and the Sons of Liberty immediately went into action. At about 11 pm, Revere was sent by Dr. Warren across the Charles River to Charlestown, on the opposite shore, where he could begin a ride to Lexington, while Dawes was sent the long way around, via the Boston Neck and the land route to Lexington.
In the days before April 18, Revere had instructed Robert Newman, the sexton of the Old North Church, to send a signal by lantern to alert colonists in Charlestown as to the movements of the troops when the information became known. In what is well known today by the phrase “one if by land, two if by sea”, one lantern in the steeple would signal the army’s choice of the land route, while two lanterns would signal the route “by water” across the Charles River. This was done to get the message through to Charlestown in the event that both Revere and Dawes were captured. Newman and Captain John Pulling momentarily held two lanterns in the Old North Church as Revere himself set out on his ride, to indicate that the British soldiers were in fact crossing the Charles River that night. Revere rode a horse lent to him by John Larkin, Deacon of the Old North Church.
enter site There were other riders that night besides Dawes, including a woman, Sybil Ludington. The other men were Israel Bissel and Samuel Prescott. a doctor who happened to be in Lexington “returning from a lady friend’s house at the awkward hour of 1 a.m.”