May 2013 archive

Cross posted from The Stars Hollow Gazette

This is your morning Open Thread. Pour your favorite beverage and review the past and comment on the future.

Find the past “On This Day in History” here.

Click on image to enlarge

May 15 is the 135th day of the year (136th in leap years) in the Gregorian calendar. There are 230 days remaining until the end of the year.

On this day in 1776, the Virginia Convention instructs its Continental Congress delegation to propose a resolution of independence from Great Britain, paving the way for the United States Declaration of Independence.

The Virginia Conventions were a series of five political meetings in the Colony of Virginiaduring the American Revolution. Because the House of Burgesses had been dissolved in 1774 by Royal Governor Lord Dunmore, the conventions served as a revolutionary provisional government until the establishment of the independent Commonwealth of Virginia in 1776.

The fifth convention began May 6, 1776 and met in Williamsburg. On May 15, the convention declared independence from Britain and adopted a set of three momentous resolutions: one calling for a declaration of rights for Virginia, one calling for establishment of a republican constitution, and a third calling for federal relations with whichever other colonies would have them and alliance with whichever foreign countries would have them. It also instructed its delegates to the Continental Congress in Philadelphia to declare independence. Virginia’s congressional delegation was thus the only one under unconditional positive instructions to declare independence; Virginia was already independent, and so its convention did not want their state, in the words of Benjamin Franklin, to “hang separately.” According to James Madison’s correspondence for that day, Williamsburg residents marked the occasion by taking down the Union Jack from over the colonial capitol and running up a continental union flag.

On June 7, Richard Henry Lee, one of Virginia’s delegates to Congress, carried out these instructions and proposed independence in the language the convention had commanded him to use: that “these colonies are, and of right ought to be, free and independent states.” This paved the way for the American Declaration of Independence, which also reflected the idea that not one nation, but thirteen free and independent states were aborning on the east coast of North America.

The convention amended, and on June 12 adopted, George Mason‘s Declaration of Rights, a precursor to the United States Bill of Rights. On June 29, the convention approved the first Constitution of Virginia, which was also the first written constitution adopted by the people’s representatives in the history of the world. The convention chose Patrick Henry as the first governor of the new Commonwealth of Virginia, and he was inaugurated on June 29, 1776. Thus, Virginia had a functioning, permanent, republican constitution before July 4, 1776 — uniquely among the thirteen American colonies.

originally published at VOTS

As a family we were never the Hallmark Card picture of any holiday, but we celebrated and enjoyed them just the same. Mother’s Day was no exception. We never did anything over the top, just cards and flowers for mom, gifts when we were flush, and a nice family dinner. The non-moms get to clean up and that is pretty much how it went for most of my life.

Now, here is where I’ll tell you a little something about my mom. My mom was smart, funny, the Aunt who was everybody’s favorite, and notoriously hard to buy a gift for. You could try, but if she opened that bugger and wasn’t thrilled with what was inside? Oh! There was no hiding that, she just couldn’t pretend. That is hard on a kid. Happily, as she got older, she started collecting things, Seraphim Angels for one, giving us all an easy out. Just add to her collection and she’d be pleased as punch. That’s over now. There’s no more pleasure or displeasure, just a distracted sense of–Oh, is it Mother’s Day?

It shouldn’t be this hard, yet somehow it is. I can’t even explain it. I loved my Grandmother as much as one could possibly love another human being, and I helped nurse her through her final year on this earth right here in the room where I sit. A series of strokes took her mobility, her speech and finally her life, and that was very hard, but it wasn’t like this. The doctor told us all that we took much better care of her than she would have ever received in long term care, she was never alone, she was always surrounded by family who loved her. It was at this time that my mother got a promise from me–no less for you, Mom, never will you be abandoned to strangers, not on my watch. That’s a promise she’s reminded me of at times over the years, not lately, because she doesn’t remember, but I do.

Dementia has stolen the Mom I knew, but not the Mom I love. Even if she doesn’t know if we’re mother and daughter or sisters that day, she still knows that she loves me and I love her. As I stood at the stove on Mother’s Day I heard her come into the kitchen, and I turned to her, “Do you need something, Mommy?” She came to me and hugged me, her eyes welling up, said my name and “Thank you, thank you so much for…” then the strings of that emotional corset pulled so tight– I couldn’t breath for a moment, my throat threatened to lock and leave me unable to speak. I heard her murmur something about what I do for her and I managed to get out, “No, we do for each other, we always have.” She pulled back and she was smiling, “Yeah, we do, don’t we?” and then she wandered away.

And that hug, it was a gift, a beautiful gift to me. But what I wouldn’t give for just one more stink-eye from Mom over a bad gift.

Cross posted from The Stars Hollow Gazette

This is your morning Open Thread. Pour your favorite beverage and review the past and comment on the future.

Find the past “On This Day in History” here.

May 14 is the 134th day of the year (135th in leap years) in the Gregorian calendar. There are 231 days remaining until the end of the year.

On this day in 1796, Edward Jenner, an English country doctor from Gloucestershire, administers the world’s first vaccination as a preventive treatment for smallpox, a disease that had killed millions of people over the centuries.

Edward Anthony Jenner (17 May 1749 – 26 January 1823) was an English scientist who studied his natural surroundings in Berkeley, Gloucestershire. Jenner is widely credited as the pioneer of smallpox vaccine, and is sometimes referred to as the “Father of Immunology”; his works have been said to have “saved more lives than the work of any other man”.

Smallpox

Lady Mary Wortley Montagu witnessed the Ottoman Empire practice of variolation during her 1716-1718 sojourn in Istanbul, where her husband was the British ambassador. She brought the idea back to Britain. Voltaire, a few years later, recorded that 60% of people caught smallpox, with 20% of the population dying of it. In the years following 1770 there were at least six people in England and Germany (Sevel, Jensen, Jesty 1774, Rendell, Plett 1791) who had successfully tested the possibility of using the cowpox vaccine as an immunization for smallpox in humans. For example, Dorset farmer Benjamin Jesty had successfully vaccinated and presumably induced immunity in his wife and two children with cowpox during a smallpox epidemic in 1774, but it was not until Jenner’s work some twenty years later that the procedure became widely understood. Indeed, Jenner may have been aware of Jesty’s procedures and success.

Jenner’s Initial Theory:

The initial source of infection was a disease of horses, called “the grease”, and that this was transferred to cows by farm workers, transformed, and then manifested as cowpox.

Noting the common observation that milkmaids did not generally get smallpox, Jenner theorized that the pus in the blisters which milkmaids received from cowpox (a disease similar to smallpox, but much less virulent) protected the milkmaids from smallpox. He may have had the advantage of hearing stories of Benjamin Jesty and others who deliberately arranged cowpox infection of their families, and then noticed a reduced smallpox risk in those families.

On 14 May 1796, Jenner tested his hypothesis by inoculating James Phipps, a young boy of 8 years (the son of Jenner’s gardener), with material from the cowpox blisters of the hand of Sarah Nelmes, a milkmaid who had caught cowpox from a cow called Blossom, whose hide hangs on the wall of the library at St George’s medical school (now in Tooting). Blossom’s hide commemorates one of the school’s most renowned alumni. Phipps was the 17th case described in Jenner’s first paper on vaccination.

Jenner inoculated Phipps with cowpox pus in both arms on the same day. The inoculation was accomplished by scraping the pus from Nelmes’ blisters onto a piece of wood then transferring this to Phipps’ arms. This produced a fever and some uneasiness but no great illness. Later, he injected Phipps with variolous material, which would have been the routine attempt to produce immunity at that time. No disease had followed. Jenner reported that later the boy was again challenged with variolous material and again showed no sign of infection.

Known:

Smallpox is more dangerous than variolation and cowpox less dangerous than variolation.

Hypothesis:

Infection with cowpox gives immunity to smallpox.

Test:

If variolation after infection with cowpox fails to produce a smallpox infection, immunity to smallpox has been achieved.

Consequence:

Immunity to smallpox can be induced much more safely than by variolation.

Ronald Hopkins states: “Jenner’s unique contribution was not that he inoculated a few persons with cowpox, but that he then proved they were immune to smallpox. Moreover, he demonstrated that the protective cowpox could be effectively inoculated from person to person, not just directly from cattle. In addition he tested his theory on a series of 23 subjects. This aspect of his research method increased the validity of his evidence.

He continued his research and reported it to the Royal Society, who did not publish the initial report. After improvement and further work, he published a report of twenty-three cases. Some of his conclusions were correct, and some erroneous – modern microbiological and microscopic methods would make this easier to repeat. The medical establishment, as cautious then as now, considered his findings for some time before accepting them. Eventually vaccination was accepted, and in 1840 the British government banned variolation – the use of smallpox itself – and provided vaccination – using cowpox – free of charge. (See Vaccination acts). The success of his discovery soon began to spread around Europe and as an example was used en masse in the Spanish Balmis Expedition a three year mission to the Americas led by Dr Francisco Javier de Balmis with the aim of giving thousands the smallpox vaccine. The expedtition was successful and Jenner wrote, “I don’t imagine the annals of history furnish an example of philanthropy so noble, so extensive as this.”

Jenner’s continuing work on vaccination prevented his continuing his ordinary medical practice. He was supported by his colleagues and the King in petitioning Parliament and was granted £10,000 for his work on vaccination. In 1806 he was granted another £20,000 for his continuing work.

Legacy

In 1979, the World Health Organization declared smallpox an eradicated disease. This was the result of coordinated public health efforts by many people, but vaccination was an essential component. And although it was declared eradicated, some samples still remain in laboratories in Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia in the United States, and State Research Center of Virology and Biotechnology VECTOR in Koltsovo, Novosibirsk Oblast, Russia.

The importance of his work does not stop there. His vaccine also laid the groundwork for modern-day discoveries in immunology, and the field he began may someday lead to cures for arthritis, AIDS, and many other diseases of the time.