Tag: Mouse Chimeras

Of Mice and Men, Chimera, and the Stem Cell Issue

Chimera (genetics)

From Wikipedia

Chimeras in research

In biological research, chimeras are artificially produced by physically mixing cells from two different organisms. Chimeras are not hybrids, […] (like a donkey and a horse) that form a single zygote that will develop as much as it can (in this case into a live mule […]);

in comparison, chimeras are the physical mixing of cells from two independent zygotes:

for example, one from the donkey and one from the horse. “Chimera” is a broad term and is often applied to many different types of mixing of cells from two different species.

Some chimeras can result in the eventual development of an adult animal composed of cells from both donors, which may be of different species – for example, in 1984 a chimeric geep was produced by combining embryos from a goat and a sheep.[8]

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Mouse chimeras  …